Our group studies cancers of the gastrointestinal tract, specifically colorectal, esophageal and pancreatic cancer. The aim is to understand the heterogeneity present within these cancers and between distinct cancer patients. For colorectal cancer, we have been instrumental in the design of molecular subtypes that identify patient groups with clearly distinctive tumors from a biological point of view. Understanding the ontogeny, molecular wiring and vulnerabilities of these molecular subtypes is key to our research program.
Team leader
Jan Paul Medema
Head of Department, Professor in Experimental Oncology and Radiobiology
Team members
Le (Larry) Zhang
PhD student
Valérie Wouters
PhD student
Lidia Atencia Taboada
PhD student
Ciro Longobardi
PhD student
Publications
- Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo modelsAbstract Colorectal cancer (CRC) is a highly heterogeneous disease both… »
- Isolation, Propagation, and Clonogenicity of Intestinal Stem CellsAbstract Intestinal stem cell research has greatly aided our understanding… »
- Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and MetastasisAbstract Evasion of apoptosis is a hallmark of cancer, which… »
- BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancerAbstract Evasion of apoptosis is a hallmark of cancer, which… »
- Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machineryAbstract Obesity is a strong risk factor for cancer progression,… »
- The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gutAbstract The rapid renewal of the epithelial gut lining is… »
Funding
- KWF
- Oncode
- ZonMW
- Stichting CCA