Stem cells are essential for the homeostasis of most adult human tissues. Previously we identified stem-like cells that fuel the growth and progression of colorectal cancers. We defined the impact of oncogenic mutations on stem cell dynamics in the intestine. We use this knowledge and associated research tools to improve chemopreventive strategies and to develop novel, and more effective therapies for colorectal cancer.
Team leader
Team members
Publications
- The Role of Small Molecules and Their Effect on the Molecular Mechanisms of Early Retinal Organoid DevelopmentEarly in vivo embryonic retinal development is a well-documented and evolutionary conserved …
- An alternative approach to produce versatile retinal organoids with accelerated ganglion cell developmentGenetically complex ocular neuropathies, such as glaucoma, are a major …
- The retinal pigmentation pathway in human albinism: Not so black and whiteAlbinism is a pigment disorder affecting eye, skin and/or hair. …
Continue reading “The retinal pigmentation pathway in human albinism: Not so black and white”
Funding
- VICI
- Oncode Institute, The New York Stem Cell Foundation