Bijlsma Group
Generating organoids from pancreatic and esophageal cancer to study tumor biology and test efficacy of novel treatments.
Complex Ophthalmogenetics
Elucidating the complex genetics of ophthalmogenetic disorders and developing rational, genomics-driven diagnostics and therapies.
CEMM – Molecular Oncology
Defining the impact of oncogenic mutations on stem cell dynamics in the intestine.
DigeST
Studying the impact of specialized nutrition on gut maturation in early life and later life gut health and understanding the mechanisms of gut regeneration and how these are recapitulated during the development of colorectal cancer.
Environmental control of the immune system
Developing 3D human lymph node organotypic cultures, in order to include the immune system in multi-organ on chip devices.
Immunohematology
Performing translational research on chronic lymphocytic leukemia (CLL), which is a prime example of a malignancy that is highly dependent on interactions with the tumor microenvironment.
Huntington Disease proteostasis group
Improving selective degradation of mHTT by the ubiquitin-proteasome system, using a combination of advanced microscopy, proteomics, peptide chemistry and biochemistry to understand & manipulate degradation of mHTT in 2D and 3D cell models.
LEXOR
Studying cancers of the gastrointestinal tract, specifically colorectal, esophageal and pancreatic cancer.
Lisa van Baarsen Lab
Studying failure of immunological tolerance in various rheumatic diseases, focusing on the interaction between stromal cells and immune cells.
OrganoVIR Labs
Studies picornaviruses, CMV, HIV and recently SARS-CoV-2 using human gut, airway, blood-brain-barrier and brain organoids.
Skinlab
Focusing on human skin and mucosa biology, and in particular in generating the next generation of animal alternative methods which can be used to develop novel therapeutic strategies for treating and preventing human disease.
RIRE (renal injury and repair)
Using iPSCs-derived kidney organoids to model congenital defects, for drug development, personalized medicine and to improve our understanding of kidney development, acute kidney injury, fibrosis, and chronic kidney disease.
Stem Cell Biology
Identifing and describing glial defects in neurodevelopmental disorders, and to perform proof-of-concept studies for glial-targeted therapy strategies using advanced stem cell technologies.
Tas Group
Mimicking the RA synovial tissue using multicellular 3D systems that recapitulate the cell-cell/cell-matrix interactions, and key pro-inflammatory mediators present in the inflamed synovium.